The 15 mg dose of L-methylfolate is MethylPro®’s most popular product. Until now, this dose level of L-methylfolate was available from MethylPro® as a standalone nutrient, or in a formula with cofactors or B-complex vitamins. What we heard from our customers was, while they love these products, most of them also sought a high-quality multivitamin to complement the work methylfolate is doing in the brain and body, filling any nutritional gaps created by the diet. We interpreted this information as a call to action. In response, we have created the new MethylPro® Multivitamin + 15 mg L-Methylfolate.
MethylPro® Multivitamin + 15 mg L-Methylfolate is a convenient way to consume an array of vital vitamins and minerals in highly bioavailable forms. The formula includes B vitamins: thiamine, riboflavin, niacin, B-6, biotin, pantothenic acid, and B-12 (as methylcobalamin); cofactors for both energy production and methylation. It contains zinc and vitamins A, C, and D to support healthy immune function. It includes choline, an important player in methylation, neurotransmitter production, homocysteine processing, and brain health. And of course, it also contains the most popular dose of MethylPro®’s L-methylfolate for mood support: 15 mg per capsule.
What makes this multivitamin with L- methylfolate unique?
This is not a multivitamin for just anyone. MethylPro® Multivitamin + 15 mg L-Methylfolate is tailored to suit the broader nutritional needs of someone who benefits from a high-dose L- methylfolate supplement.
Methylfolate, L-methylfolate specifically, is the active form of folate that crosses the blood-brain barrier and works throughout the body with no need for internal processing. This is different from folic acid, which is the form of folate found in most folate-containing supplements and fortified foods. Folic acid requires several steps of processing within the body before it can be used to fulfill folate’s physiological roles. Unfortunately, due to genetics and epigenetic conditions, approximately half of the general population and at least 70% of those with depressive disorders cannot process folic acid effectively . As folate is integral to the production and signaling of neurotransmitters such as serotonin, poor folate processing can lead to a significant mood imbalance. This factor likely contributes to many cases of SSRI resistance .
Many people who have struggled with mood imbalance have found that nutritional support with an L-methylfolate supplement, such as MethylPro®, can help. L-methylfolate supplements are quicker and more effective than folic acid for raising circulating levels of active folate, regardless of genetics . Methylfolate supplements can quickly provide folate needed for normal neurotransmitter production, new cell growth, cardiovascular health, and proper nerve function.
Ok, but what, besides methylfolate, makes this multivitamin unique?
Like folate, choline is another important precursor for neurotransmitter production. Choline is also a methyl donor for methylation and protects the structural integrity of brain cells and cognitive function . This is a fairly unique addition to a multivitamin formula, but an estimated 75% of Americans are consuming insufficient levels of choline for their health . This statistic gets significantly bleaker with age. Therefore, choline is a valuable asset to the MethylPro® Multivitamin + 15 mg L-Methylfolate formula.
Vitamin D deficiency is another underpublicized epidemic in the US. It is difficult to make enough vitamin D from sun exposure living a modern, mostly-indoor lifestyle. Among its known benefits, vitamin D is essential for bone health, mood balance, and immune function. Related to its role within the immune system, there are several studies pointing to a direct association between vitamin D deficiency and COVID-19 severity . MethylPro® Multivitamin + 15 mg L-Methylfolate contains 2000 IU of cholecalciferol (D-3), the same form of vitamin D made by your body naturally in response to sunlight. 2000 IU is a significant dose of vitamin D and is both clinically relevant and appropriate for helping most people reach healthy levels of circulating vitamin D .
What if I am already taking a 15 mg methylfolate supplement and a multivitamin?
If you are already taking a high-dose methylfolate supplement and a multi, MethylPro® Multivitamin + 15 mg L-Methylfolate can replace both of those products with a single daily capsule. This literally reduces the number of pills you have to swallow, but it also makes life easier in terms of online shopping, remembering to reorder, and choosing products that are complementary to one another.
As we are still weathering the unknown aftershocks of a global pandemic, none of us need additional stressors in our lives. However, it is especially important to simplify potential sources of anxiety and make healthy choices when we have depressive tendencies. Please let us help you cut out one step from your daily routine and support your nutritional wellbeing. Replace your methylfolate supplement and daily multivitamin with a high-quality, all-in-one formula designed to nurture a healthy mind and a balanced body.
- LeBano, Lauren. “L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression?” Psyche Congress Network. May 8, 2013. www.psychcongress.com/article/l-methylfolate-promising-therapy-treatment-resistant-depression
- Kose, Samet, and Kemal Sayar. “L-methylfolate in patients with treatment resistant depression: fulfilling the goals of personalized psychopharmacological therapy.” (2018): 359-362.
- Poly, Coreyann, et al. “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.” The American journal of clinical nutrition 94.6 (2011): 1584-1591.
- Blusztajn JK, Slack BE, Mellott TJ. Neuroprotective Actions of Dietary Choline. Nutrients. 2017; 9(8):815. https://doi.org/10.3390/nu9080815
- Runestad, Todd. “Congress lauds vitamin D for COVID-19”. Natural Products Insider. Feb 25, 2021. https://www.naturalproductsinsider.com/ingredients/congress-lauds-vitamin-d-covid-19?utm_source=Bibblio&utm_campaign=Related
- Bischoff-Ferrari, Heike A., et al. “Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.” The American journal of clinical nutrition 84.1 (2006): 18-28.