In the realm of health and wellness, acronyms like MTHFR can seem like a secret code. Today we’re demystifying this puzzling abbreviation. We will shed light on why genetic testing for MTHFR mutations might just be the key to unlocking better health.


Let’s start with the basics. MTHFR stands for methylenetetrahydrofolate reductase. The name is quite a mouthful. It refers to an enzyme that is crucial for processing folate in your body. Think of it as a molecular gatekeeper responsible for converting folate into its active form. We need the active form, methylfolate (or l-methylfolate), for various bodily functions, including DNA synthesis and repair, neurotransmitter production, and detoxification.

The MTHFR gene codes for the MTHFR enzyme. When the MTHFR gene undergoes mutations, it can affect the enzyme’s efficiency. This can lead to a decreased ability to convert folate into l-methylfolate. The manifestations of these mutations are called gene variants. Variants have potential to wreak havoc on your health, manifesting in a myriad of ways, from mild to severe.

The Puzzle Pieces: Signs of MTHFR Variants

Wondering if you might have an MTHFR variant? While the signs can vary widely and may overlap with other health issues, some common signs include:

  • Fatigue that just won’t quit
  • Mood swings or a chronically low mood
  • Brain fog and memory issues
  • Fertility struggles
  • Ongoing physical discomfort in the body or head

Why Genetic Testing Matters

Given the broad spectrum of ways in which MTHFR mutations present themselves, it’s easy to see why getting to the root cause is crucial. Enter genetic testing: a powerful tool that allows you to peek into your DNA. It can uncover any lurking mutations, including those in the MTHFR gene.

By undergoing genetic testing, you’re not just playing detective; you’re arming yourself with valuable information that can guide personalized treatment and preventive strategies. Knowing whether you have an MTHFR variant empowers you to take proactive steps to optimize your health and potentially mitigate associated risks.

Where to Go for Genetic Testing?

You can ask your trusted healthcare practitioner to conduct a genetic test for you, or you can choose a company you trust to conduct genetic testing for MTHFR. Consider looking into companies like GeneSight, Genomind, or EpigeneticsRX.

These companies go beyond printing you a list of gene acronyms that you have to decipher. They employ experts who can tell you how your unique genetic makeup is related to your current health challenges. They can also explain how your body is likely to process the things you ingest. This information is useful for your doctor, to help you come up with a health plan based around your individualized genetic needs. 

If you are considering genetic testing for MTHFR due to a long-term mood issue, specifically, results from these tests can also explain why certain products that help many others haven’t worked for you. 

The Methylfolate Connection

So, you’ve got your genetic test results. Lo and behold, you find you have a common MTHFR variant staring back at you. Now what? Enter methylfolate, the superhero of the folate world.

Methylfolate, also known as l-methylfolate or 5-MTHF, is the active form of folate that your body can readily use. Supplementing in this form bypasses the need for MTHFR to do its conversion magic. By supplementing with methylfolate, you’re essentially sidestepping any potential roadblocks caused by MTHFR mutations, ensuring your body gets the folate it needs to thrive.

Navigating the Supplement Maze

With methylfolate in hand, you’re ready to embark on your journey to better health. But before you rush to the nearest supplement aisle, a word of caution: not all methylfolate supplements are created equal.

When choosing a methylfolate supplement, opt for quality over quantity. Look for reputable brands that use bioavailable forms of methylfolate and avoid fillers and unnecessary additives. Your doctor is likely to recommend MethylPro for these reasons. 

Not only is MethylPro clean and high-quality, but it also comes in a broad range of potencies, so you can supplement with the exact same ingredient in different amounts, depending on the supplemental regimen you design with your doctor. Starting with a low dose and gradually titrating up if needed can help you gauge your body’s response and minimize potential side effects.

Beyond Methylfolate: A Holistic Approach

While methylfolate certainly plays a starring role in MTHFR management, it’s essential to adopt a holistic approach to optimize your health. This means paying attention to other key factors that can influence methylation and gene expression, such as:

  • Nutrition: Load up on folate-rich foods like leafy greens, legumes, and citrus fruits, and consider supplementing with other B vitamins that support methylation, like B12 and B6.
  • Lifestyle: Prioritize stress management techniques like meditation and yoga, prioritize quality sleep, and steer clear of environmental toxins whenever possible.
  • Supportive Practices: Explore complementary practices like acupuncture, massage, and infrared sauna sessions to support detoxification and overall well-being.

Another reason to choose MethylPro is the option for added nutritional benefits. If you are taking our research-based high-dose 15 mg formula, there is an option to switch to our Multivitamin + 15 mg so you are not only getting methylfolate but also a high-caliber full-spectrum multivitamin/mineral every day. Alternatively, we offer methylfolate in multiple doses formulated with cofactors (B12, B6, and Magnesium) or in combination with a full B-Complex. 

The Bottom Line

In the grand tapestry of health, genetic testing for MTHFR mutations is but one thread, but it is a crucial one. By embracing the power of knowledge and taking proactive steps to support your body’s unique needs, you’re not just managing your health—you’re on the road to thriving.

So, if you’ve been grappling with unexplained symptoms or suspect there might be more to your health story, consider embarking on the journey of genetic testing for MTHFR. Who knows? It might just be the missing piece of the puzzle you’ve been searching for all along.

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